Does anyone know the best time of day to apply bioidentical hormone replacement therapy cream for menopause?

My mother was prescribed a bioidentical hormone in the form of a cream for her menopause. She is wondering if anyone knew the best time of day to apply the cream of does it not matter? Any help is appreciated. Thanks!

Tagged as: anyone, apply, best, bioidentical, Cream, Hormone, know, Menopause, Replacement, Therapy, time